Reference
Reference TypeSubmission
TitleLarge scale analysis of peptide-HLA class I interactions
AuthorsMikkel Harndahl; Kasper Lamberth; Sune Justesen; Gustav Røder; Michael Madsen; Morten Nielsen; Claus Lundegaard; Mette Voldby Larsen; Sheila Tang; Søren Brunak; Ole Lund; Søren Buus
AffiliationsDiv of Experimental Immunology, Dep Med Microbiol Immunol, University of Copenhagen, Cntr Biol Seq Anal, Technical University of Denmark.
SubmitterOle Lund
Year2007
AbstractIn general, this data has been generated using a quantitative biochemical peptide-HLA interaction assay (see PMID: 12135423). The HLA class I molecules have been selected to cover the known HLA supertypes (using PMID: 14963618). Predictions of peptide binding to HLA class I has been performed using various bioinformatics approaches including artificial neural networks (see PMID: 14617044 and PMID: 12717023 peptides and using a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions (PMID: 15997466). In many cases, the most informative peptides have been selected using a Query-by-Committeee procedure (using PMID: 14617044 and PMID: 14629874).
Curation Last Updated2024-11-04 20:01:21
Epitope
Epitope ID66891
Chemical TypeLinear peptide
Linear SequenceTTTYKAFDW
Source Molecule NameImmunogenic protein MPB64 precursor
Source OrganismMycobacterium tuberculosis variant bovis
Starting Position126
Ending Position134
Epitope Reference Details
Epitope Structure DefinesExact Epitope
Reference Starting Position126
Reference Ending Position134
In Vivo Processing
Host OrganismHomo sapiens (human)
MHC Ligand Assay
Qualitative MeasurementPositive-Intermediate
Method/Techniquepurified MHC/direct/fluorescence
Measurement ofdissociation constant KD (~EC50)
Assay Type UnitsnM
Measurement Details
Measurement Inequality=
Quantitative measurement71.3
MHC Allele
MHC Allele NameHLA-B*58:01