| Reference | ||
|---|---|---|
| Reference Type | Literature | IEDB_Reference:621 |
| Title | HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase. | |
| Authors | Yuzhi Dong; Sandra Demaria; Xuming Sun; Fabio R Santori; Bill M Jesdale; Anne S De Groot; William N Rom; Yuri Bushkin | |
| Affiliations | Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103, USA. | |
| Journal | Infect Immun | |
| Year | 2004 | |
| Abstract | Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins. | |
| Curation Last Updated | 2023-08-18 20:01:47 | |
| Epitope | ||
|---|---|---|
| Epitope ID | 37084 | IEDB_epitope:37084 |
| Chemical Type | Linear peptide | |
| Linear Sequence | LLAFTNPTV | |
| Source Molecule Name | glutamine synthetase GLNA1 (glutamine synthase) (GS-I) | |
| Source Organism | Mycobacterium tuberculosis | |
| Starting Position | 316 | |
| Ending Position | 324 | |
| Epitope Reference Details | ||
|---|---|---|
| Epitope Structure Defines | Exact Epitope | |
| Epitope Name | GlnS316-324 | |
| Reference Starting Position | 316 | |
| Reference Ending Position | 324 | |
| Location of Data in Reference | Table 1 | |
| In Vivo Processing | ||
|---|---|---|
| Host Organism | Homo sapiens (human) | |
| MHC Ligand Assay | ||
|---|---|---|
| Qualitative Measurement | Positive | |
| Method/Technique | cellular MHC/direct/fluorescence | |
| Measurement of | half life | |
| Assay Type Units | min | |
| Measurement Details | ||
|---|---|---|
| Quantitative measurement | 480 | |
| MHC Allele | ||
|---|---|---|
| MHC Allele Name | HLA-A*02:01 | |
| Assay Reference Details | ||
|---|---|---|
| Assay Comments by IEDB Curator | DC50 (dissociation complex) is the time required for the loss of 50% of peptide-ligand HLA-A2 complexes stabilized at the T2 cell surface after overnight culture with 100 micromolar peptide and 100 ng of β2-microglobulin/ml. The reported response was >8. | |
| Location of Assay Data in Reference | Table 1 | |