alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc epitope

EPITOPE SUMMARY
alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc (epitope ID 122244 ) has this structure: CHEBI:59034 studied as part of Cry j 1 (UniProt:P18632) from Cryptomeria japonica (Japanese cedar) and glucan endo-1,3-beta-D-glucosidase (UniProt:A0A6A6KJF1) from Hevea brasiliensis (rubbertree). The epitope has these synonyms: alpha-L-fucopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->6)]-[beta-D-xylopyranosyl-(1->2)]-beta-D-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-acetamido-2-deoxy-D-glucopyranose, 6-deoxy-alpha-L-galactopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->6)]-[beta-D-xylopyranosyl-(1->2)]-D-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-acetamido-2-deoxy-alpha-D-glucopyranose, alpha-D-Manp-(1->6)-[alpha-D-Manp-(1->3)]-[beta-D-Xylp-(1->2)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, alpha-L-Fuc-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)]-beta-D-GlcNAc, alpha-L-fucosyl-(1->3)-[alpha-D-mannosyl-(1->3)-[alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)]-N-acetyl-beta-D-glucosamine, alpha-L-Fucp-(1->3)-[alpha-D-Manp-(1->3)-[alpha-D-Manp-(1->6)]-[beta-D-Xylp-(1->2)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)]-beta-D-GlcpNAc, alpha-Man-(1->6)-[alpha-Man-(1->3)]-[beta-Xyl-(1->2)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-[alpha-Fuc-(1->3)]-beta-GlcNAc, Fucalpha1-3[Manalpha1-3(Manalpha1-6)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4]GlcNAcbeta, Hev b 2 oligosaccharide, O-6-deoxy-alpha-L-galactopyranosyl-(1->3)-O-[O-alpha-D-mannopyranosyl-(1->3)-O-[alpha-D-mannopyranosyl-(1->6)]-O-[beta-D-xylopyranosyl-(1->2)]-O-beta-D-mannopyranosyl-(1->4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy-beta-D-glucopyranose, PHA N-glycan, untreated PHA N-glycan, untreated phytohemagglutinin N-glycan, WURCS=2.0/5,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a1122h-1b_1-5][a212h-1b_1-5][a1122h-1a_1-5]/1-2-1-3-4-5-5/a3-b1_a4-c1_c4-d1_d2-e1_d3-f1_d6-g1, N-glycan heptasaccharide. This epitope has been studied for immune reactivity in 4 publication(s), tested in 3 T cell assays and 8 B cell assays.

EPITOPE SUMMARY

alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc (epitope ID

122244

) has this structure:

CHEBI:59034

studied as part of Cry j 1 (UniProt:P18632) from Cryptomeria japonica (Japanese cedar) and glucan endo-1,3-beta-D-glucosidase (UniProt:A0A6A6KJF1) from Hevea brasiliensis (rubbertree). The epitope has these synonyms: alpha-L-fucopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->6)]-[beta-D-xylopyranosyl-(1->2)]-beta-D-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-acetamido-2-deoxy-D-glucopyranose, 6-deoxy-alpha-L-galactopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->6)]-[beta-D-xylopyranosyl-(1->2)]-D-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-acetamido-2-deoxy-alpha-D-glucopyranose, alpha-D-Manp-(1->6)-[alpha-D-Manp-(1->3)]-[beta-D-Xylp-(1->2)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc, alpha-L-Fuc-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)]-beta-D-GlcNAc, alpha-L-fucosyl-(1->3)-[alpha-D-mannosyl-(1->3)-[alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)]-N-acetyl-beta-D-glucosamine, alpha-L-Fucp-(1->3)-[alpha-D-Manp-(1->3)-[alpha-D-Manp-(1->6)]-[beta-D-Xylp-(1->2)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)]-beta-D-GlcpNAc, alpha-Man-(1->6)-[alpha-Man-(1->3)]-[beta-Xyl-(1->2)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-[alpha-Fuc-(1->3)]-beta-GlcNAc, Fucalpha1-3[Manalpha1-3(Manalpha1-6)(Xylbeta1-2)Manbeta1-4GlcNAcbeta1-4]GlcNAcbeta, Hev b 2 oligosaccharide, O-6-deoxy-alpha-L-galactopyranosyl-(1->3)-O-[O-alpha-D-mannopyranosyl-(1->3)-O-[alpha-D-mannopyranosyl-(1->6)]-O-[beta-D-xylopyranosyl-(1->2)]-O-beta-D-mannopyranosyl-(1->4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy-beta-D-glucopyranose, PHA N-glycan, untreated PHA N-glycan, untreated phytohemagglutinin N-glycan, WURCS=2.0/5,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a1122h-1b_1-5][a212h-1b_1-5][a1122h-1a_1-5]/1-2-1-3-4-5-5/a3-b1_a4-c1_c4-d1_d2-e1_d3-f1_d6-g1, N-glycan heptasaccharide. This epitope has been studied for immune reactivity in

publication(s), tested in

T cell assays and

B cell assays.

CURATED EXPERIMENTAL DATA
B Cell Assay(s) 8
Assay Type	Positive / All
qualitative binding	7 / 7
histamine release	1 / 1

T Cell Assay(s) 3
Assay Type	Positive / All
IFNg release	0 / 1
IL-4 release	0 / 1
proliferation	0 / 1

EXTERNAL RESOURCES
Resource	Link
PubChem	45480564
GlyTouCan	G26295XE