EPITOPE SUMMARY
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine (epitope ID
130694
) has this structure:
CHEBI:466659
. The epitope has these synonyms: N-[(2S,3S,4R)-1-(alpha-D-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide, (2S,3S,4R)-1-O-(alpha-D-galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol, 1-O-(alpha-D-galactopyranosyl)-N-hexacosanoylphytosphingosine, alpha-GalCer, alpha-GalCer(t18:0/26:0), alpha-GC (C26), alpha-GC(C26), Galalpha-Cer(t18:0/26:0), KRN 7000, KRN7000. This epitope has been studied for immune reactivity in
136
publication(s), tested in
630
T cell assays,
9
B cell assays,
22
MHC ligand assays and has 3D structure(s)
4LHU
,
3HE7
,
6BNK
,
3HE6
,
3HUJ
,
1ZT4
,
2PO6
and
4EN3
.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
22
MHC moleculePositive / All
mouse CD1d
13
/
13
human CD1d
9
/
9
B Cell Assay(s)
9
Assay TypePositive / All
qualitative binding
4
/
6
dissociation constant KD
1
/
1
off rate
1
/
1
on rate
1
/
1
T Cell Assay(s)
630
Assay TypePositive / All
qualitative binding
111
/
112
IFNg release
104
/
105
IL-4 release
83
/
84
IL-2 release
61
/
61
dissociation constant KD
51
/
52
proliferation
26
/
28
on rate
24
/
24
activation
19
/
20
off rate
19
/
19
IL-13 release
17
/
17
IL-10 release
11
/
12
IL-17 release
10
/
11
antibody help
10
/
10
GM-CSF release
8
/
8
TNFa release
8
/
8
3D structure
7
/
7
IL-17A release
7
/
7
IL-12 release
5
/
6
IL-5 release
5
/
6
tumor burden after challenge
4
/
6
disease exacerbation
4
/
4
decreased disease
3
/
3
IL-6 release
3
/
3
CCL4/MIP-1b release
2
/
2
cytotoxicity
2
/
2
pathogen burden after challenge
2
/
2
T cell help
2
/
2
TNF release
2
/
2
CXCL10/IP-10 release
1
/
1
granzyme A release
1
/
1
granzyme B release
1
/
1
IL-1b release
1
/
1
survival after tumor challenge after adoptive transfer
1
/
1
survival from pathogen challenge
1
/
1
IL-23 release
0
/
1
EXTERNAL RESOURCES
ResourceLink
PubChem
2826713
GlyTouCan
G09546QO