alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group epitope

EPITOPE SUMMARY
alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group (epitope ID 135815 ) has this structure: CHEBI:17785 studied as part of alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer, glycolipid, Envelope glycoprotein (UniProt:P03385) from Murine leukemia virus (murine leukemia virus MLV), Mucin TcMUCII, putative (UniProt:Q4E5Y0) from Trypanosoma cruzi, alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc and Laminin subunit alpha-1 (UniProt:P19137) from Mus musculus (mouse). The epitope has these synonyms: alpha-D-galactopyranosyl-(1->3) beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl, alpha-D-galactopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl, alpha-D-Gal(1->3)-beta-D-Gal(1->4)-D-GlcNAc-yl group, alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-D-GlcNHAc-R, alpha-D-galactopyranosyl-(1->3) beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl group, alpha-D-Galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R, alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl group, alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R, alpha-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl group, alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp-NAc-yl group, alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNHAc-R, alpha-gal, alpha-Gal trisaccharide, alpha-Gal trisaccharide epitope, alpha-Gal3, alpha-galactosyl epitope, Gal(alpha1->3)-Gal(beta1->4)-GlcNAc-R, Galalpha1-3Galbeta1-4GlcNAc-, Galalpha1-3LacNAc-. This epitope has been studied for immune reactivity in 115 publication(s), tested in 2 T cell assays and 488 B cell assays.

EPITOPE SUMMARY

alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group (epitope ID

) has this structure:

studied as part of alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer, glycolipid, Envelope glycoprotein (UniProt:P03385) from Murine leukemia virus (murine leukemia virus MLV), Mucin TcMUCII, putative (UniProt:Q4E5Y0) from Trypanosoma cruzi, alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc and Laminin subunit alpha-1 (UniProt:P19137) from Mus musculus (mouse). The epitope has these synonyms: alpha-D-galactopyranosyl-(1->3) beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl, alpha-D-galactopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl, alpha-D-Gal(1->3)-beta-D-Gal(1->4)-D-GlcNAc-yl group, alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-D-GlcNHAc-R, alpha-D-galactopyranosyl-(1->3) beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranosyl group, alpha-D-Galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R, alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl group, alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R, alpha-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl group, alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp-NAc-yl group, alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNHAc-R, alpha-gal, alpha-Gal trisaccharide, alpha-Gal trisaccharide epitope, alpha-Gal3, alpha-galactosyl epitope, Gal(alpha1->3)-Gal(beta1->4)-GlcNAc-R, Galalpha1-3Galbeta1-4GlcNAc-, Galalpha1-3LacNAc-. This epitope has been studied for immune reactivity in

115

publication(s), tested in

T cell assays and

488

B cell assays.

CURATED EXPERIMENTAL DATA
B Cell Assay(s) 488
Assay Type	Positive / All
qualitative binding	378 / 412
agglutination	21 / 21
tolerance	12 / 13
neutralization	8 / 8
complement-dependent cytotoxicity	7 / 7
decreased disease	5 / 5
antibody-dependent cellular cytotoxicity	4 / 4
dissociation constant KD	4 / 4
opsonization	4 / 4
decreased disease after adoptive transfer	2 / 2
disease exacerbation	2 / 2
tolerance after adoptive transfer	2 / 2
antibody activity inhibition	1 / 1
histamine release	1 / 1
off rate	1 / 1
on rate	1 / 1

T Cell Assay(s) 2
Assay Type	Positive / All
proliferation	2 / 2