EPITOPE SUMMARY
alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine (epitope ID
137345
) has this structure:
CHEBI:18216
. The epitope has these synonyms: (2S,3R,4E)-2-(acylamino)-3-hydroxyoctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-[beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, (Gal)2 (GalNAc)1 (Glc)1 (Neu5Ac)1 (Cer)1, alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')--N-acylsphing-4-enine, beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer, beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer, D-Galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine, D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide, Gal(beta1-3)GalNAc(beta1-4)[Neu5Ac(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer, Galbeta1-3GalNAcbeta1-4(Neu5Acalpha2-3)Galbeta1-4Glcbeta1-1Cer, ganglioside GM1, GM1, GM1a, monosialo GM1, monosialoganglioside-GM1. This epitope has been studied for immune reactivity in
64
publication(s), tested in
5
T cell assays,
181
B cell assays and
1
MHC ligand assay.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
1
MHC moleculePositive / All
human CD1b
1
/
1
B Cell Assay(s)
182
Assay TypePositive / All
qualitative binding
130
/
177
antibody binding
1
/
1
dissociation constant KD
1
/
1
off rate
1
/
1
survival from pathogen challenge
1
/
1
disease exacerbation after adoptive transfer
0
/
1
T Cell Assay(s)
5
Assay TypePositive / All
IFNg release
1
/
1
IL-2 release
1
/
1
IL-4 release
1
/
1
proliferation
1
/
1
qualitative binding
1
/
1