EPITOPE SUMMARY
Ac-Val-Chg-Arg-Tic-Phe-NH2 (epitope ID
224548
) has this structure:
CHEBI:76719
. The epitope is an analog of: VVHFF + ACET(V1) from Homo sapiens (human) Myelin basic protein. The epitope has these synonyms: N-{[(3S)-2-(N-acetyl-L-valyl-N-cyclohexylglycyl-L-arginyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl}-L-phenylalaninamide, Av-V-Chg-R-Tic-F-NH2, PV-267. This epitope has been studied for immune reactivity in
1
publication(s), tested in
27
T cell assays,
1
B cell assay and
2
MHC ligand assays.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
2
MHC moleculePositive / All
HLA-DRB1*01:01
1
/
1
HLA-DRB1*15:01
1
/
1
B Cell Assay(s)
1
Assay TypePositive / All
qualitative binding
0
/
1
T Cell Assay(s)
27
Assay TypePositive / All
decreased disease
1
/
1
decreased disease after adoptive transfer
1
/
1
activation
0
/
1
CCL2/MCP-1 release
0
/
1
CCL3/MIP-1a release
0
/
1
CCL4/MIP-1b release
0
/
1
CCL5/RANTES release
0
/
1
CXCL10/IP-10 release
0
/
1
G-CSF release
0
/
1
GM-CSF release
0
/
1
IFNg release
0
/
1
IL-10 release
0
/
1
IL-12 release
0
/
1
IL-13 release
0
/
1
IL-15 release
0
/
1
IL-17 release
0
/
1
IL-1a release
0
/
1
IL-1b release
0
/
1
IL-2 release
0
/
1
IL-4 release
0
/
1
IL-5 release
0
/
1
IL-6 release
0
/
1
IL-7 release
0
/
1
IL-8 release
0
/
1
IL-9 release
0
/
1
TNFa release
0
/
1
VEGF release
0
/
1
EXTERNAL RESOURCES
ResourceLink
PubChem
72715806