5-(2-oxopropylideneamino)-6-D-ribitylaminouracil epitope

EPITOPE SUMMARY
5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (epitope ID 226915 ) has this structure: CHEBI:78398 . The epitope has these synonyms: 1-deoxy-1-({2,6-dioxo-5-[(EE)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil, 5-OP-RU. This epitope has been studied for immune reactivity in 17 publication(s), tested in 176 T cell assays, 25 MHC ligand assays and has 3D structure(s) 5D7L , 5D7J , 7LLI , 4PJ7 , 4PJ9 , 4PJC , 5D5M , 6MWR , 6PUC , 4PJA , 4PJ8 , 4PJD , 4PJB , 6XQP , 4NQD and 4NQC .

EPITOPE SUMMARY

5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (epitope ID

) has this structure:

. The epitope has these synonyms: 1-deoxy-1-({2,6-dioxo-5-[(EE)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil, 5-OP-RU. This epitope has been studied for immune reactivity in

publication(s), tested in

176

T cell assays,

MHC ligand assays and has 3D structure(s)

and

CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s) 25
MHC molecule	Positive / All
human MR1	22 / 22
human MR1 K43A mutant	2 / 2
human MR1 R9H mutant	0 / 1

T Cell Assay(s) 176
Assay Type	Positive / All
qualitative binding	68 / 70
dissociation constant KD	40 / 40
IFNg release	20 / 20
3D structure	17 / 17
activation	7 / 8
granzyme B release	2 / 2
IL-17A release	2 / 2
TNF release	2 / 2
TNFa release	2 / 2
IL-2 release	1 / 2
CCL3/MIP-1a release	1 / 1
cytotoxicity	1 / 1
degranulation	1 / 1
GM-CSF release	1 / 1
IL-10 release	1 / 1
IL-13 release	1 / 1
IL-4 release	1 / 1
proliferation	1 / 1
CCL2/MCP-1 release	0 / 1
IL-12 release	0 / 1
IL-6 release	0 / 1

EXTERNAL RESOURCES
Resource	Link
PubChem	86289574
GlyTouCan	G01001BP