| Reference |
|---|
| Reference Type | Literature | IEDB_Reference:1001817 |
| Title | CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. | |
| Authors | Angus J MacDonald; Margaret Duffy; Miriam T Brady; Susan McKiernan; William Hall; John Hegarty; Michael Curry; Kingston H G Mills | |
| Affiliations | Immune Regulation Research Group, Department of Biochemistry, Trinity College Dublin, Ireland. | |
| Journal | J Infect Dis | |
| Year | 2002 | |
| Abstract | The factors that determine persistence or clearance of hepatitis C virus (HCV) infection are poorly understood. The CD4 T cell responses to the HCV core protein were examined in a cohort of women infected with a single genotype of HCV. CD4 T cells from HCV-infected patients secreted interferon (IFN)-gamma in response to peptides from 4 immunodominant regions of the core protein, and these responses were stronger in persistently infected women. Interleukin (IL)-10 was also produced by CD4 T cells from HCV-infected subjects in response to the same core peptides. Furthermore, HCV core-specific CD4 T cell clones secreted either IFN-gamma or IL-10 but not IL-4. These findings demonstrate that T helper type 1 and regulatory T cells are induced against the same epitopes on the core protein during HCV infection. | |
| Curation Last Updated | 2023-08-18 20:11:58 | |