EPITOPE SUMMARY
LYLVCGERG is a linear peptidic epitope (epitope ID
102639
) studied as part of Insulin (UniProt:P01308) from Homo sapiens (human), Insulin-1 (UniProt:P01325) from Mus musculus (mouse), Insulin, isoform 2 (UniProt:F8WCM5) from Homo sapiens (human) and Insulin-2 (UniProt:P01326) from Mus musculus (mouse). This epitope has been studied for immune reactivity in
24
publication(s), tested in
70
T cell assays,
8
MHC ligand assays and has 3D structure(s)
4WDI
.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
8
MHC moleculePositive / All
H2-Kd
4
/
5
HLA-A*02:01
1
/
2
HLA-A2
1
/
1
T Cell Assay(s)
70
Assay TypePositive / All
IFNg release
19
/
22
proliferation
9
/
10
qualitative binding
8
/
10
cytotoxicity
8
/
8
disease exacerbation after adoptive transfer
3
/
4
IL-2 release
3
/
3
CCL4/MIP-1b release
1
/
1
CCL5/RANTES release
1
/
1
CXCL10/IP-10 release
1
/
1
decreased disease
1
/
1
decreased disease after adoptive transfer
1
/
1
disease exacerbation
1
/
1
dissociation constant KD
1
/
1
TNF release
1
/
1
TNFa release
1
/
1
tolerance
1
/
1
type IV hypersensitivity (DTH)
1
/
1
IL-10 release
0
/
1
IL-4 release
0
/
1
EXTERNAL RESOURCES
ResourceLink
IEDB-AR: MHC-I Processing
Predict MHC class I processing
IEDB-AR: MHC-I
Predict MHC class I binding affinity
IEDB-AR: B cell scales
Predict B cell epitopes