EPITOPE SUMMARY
GILGFVFTL is a linear peptidic epitope (epitope ID
20354
) studied as part of Matrix protein 1 (UniProt:P03485) from Influenza A virus. This epitope has been studied for immune reactivity in
284
publication(s), tested in
635
T cell assays,
5
B cell assays,
117
MHC ligand assays and has 3D structure(s)
5JHD
,
1HHI
,
2VLJ
,
5EUO
,
2VLL
,
1OGA
,
2VLR
,
2VLK
,
5E6I
,
5ISZ
,
5TEZ
and
4NT6
.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
117
MHC moleculePositive / All
HLA-A*02:01
77
/
77
HLA-A2
10
/
10
HLA-A*02:06
4
/
5
HLA-A*02:02
4
/
4
HLA-A*02:03
4
/
4
HLA-C*08:01
4
/
4
HLA-A*68:02
1
/
3
HLA-E
0
/
2
HLA-E*01:03
1
/
1
SLA-3*02:02
1
/
1
HLA-A*01:01
0
/
1
HLA-A*03:01
0
/
1
HLA-A*11:01
0
/
1
HLA-A*24:02
0
/
1
HLA-A3
0
/
1
HLA-DRA*01:01/DRB1*01:01
0
/
1
B Cell Assay(s)
5
Assay TypePositive / All
qualitative binding
4
/
4
complement-dependent cytotoxicity
1
/
1
T Cell Assay(s)
635
Assay TypePositive / All
IFNg release
185
/
192
qualitative binding
174
/
179
cytotoxicity
80
/
84
dissociation constant KD
28
/
36
proliferation
19
/
20
TNFa release
16
/
17
off rate
14
/
14
on rate
14
/
14
activation
12
/
13
3D structure
9
/
9
IL-2 release
7
/
8
CCL4/MIP-1b release
7
/
7
pathogen burden after challenge
6
/
7
granzyme B release
6
/
6
perforin release
6
/
6
degranulation
5
/
6
survival from pathogen challenge
5
/
6
TNF release
3
/
4
binding constant
1
/
1
CXCL9/MIG release
1
/
1
decreased disease
1
/
1
IL-12 release
1
/
1
T cell- APC binding
1
/
1
IL-10 release
0
/
1
IL-4 release
0
/
1
EXTERNAL RESOURCES
ResourceLink
IEDB-AR: MHC-I Processing
Predict MHC class I processing
IEDB-AR: MHC-I
Predict MHC class I binding affinity
IEDB-AR: B cell scales
Predict B cell epitopes