EPITOPE SUMMARY
SVYDFFVWL is a linear peptidic epitope (epitope ID
62404
) studied as part of L-dopachrome tautomerase (UniProt:P40126) from Homo sapiens (human), L-dopachrome tautomerase (UniProt:P29812) from Mus musculus (mouse) and Isoform 2 of L-dopachrome tautomerase (UniProt:P40126-2) from Homo sapiens (human). This epitope has been studied for immune reactivity in
29
publication(s), tested in
45
T cell assays,
16
B cell assays,
9
MHC ligand assays and has 3D structure(s)
4HX1
.
CURATED EXPERIMENTAL DATA
MHC Ligand Assay(s)
9
MHC moleculePositive / All
HLA-A*02:01
5
/
5
H2-Kb
2
/
2
H2-Db
1
/
1
HLA-A*68:02
1
/
1
B Cell Assay(s)
16
Assay TypePositive / All
dissociation constant KD
4
/
4
off rate
4
/
4
on rate
4
/
4
secondary in vitro activity
2
/
2
antibody-dependent cellular cytotoxicity
1
/
1
qualitative binding
1
/
1
T Cell Assay(s)
45
Assay TypePositive / All
IFNg release
18
/
18
qualitative binding
8
/
9
proliferation
5
/
5
tumor burden after challenge
4
/
4
cytotoxicity
2
/
2
activation
1
/
1
disease exacerbation
1
/
1
IL-2 release
1
/
1
protection from tumor challenge
1
/
1
survival from tumor challenge
1
/
1
tumor burden after challenge after adoptive transfer
1
/
1
decreased disease
0
/
1
EXTERNAL RESOURCES
ResourceLink
IEDB-AR: MHC-I Processing
Predict MHC class I processing
IEDB-AR: MHC-I
Predict MHC class I binding affinity
IEDB-AR: B cell scales
Predict B cell epitopes